Pyrrolidine dithiocarbamate sensitizes U251 brain glioma cells to temozolomide via downregulation of MGMT and BCL-XL

The current study investigated the effect of pyrrolidine dithiocarbamate (PDTC) on the proliferation, apoptosis, cell cycle and sensitivity to temozolomide (TMZ) of the U251 glioma cell line. Proliferation, apoptosis and cell cycle analysis of U251 cells following treatment with PDTC and TMZ was det...

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Pubblicato in:Oncol Lett
Autori principali: Tang, Jun-Hai, Huang, Guo-Hao, Mou, Ke-Jie, Zhang, Eric Erquan, Li, Ningning, Du, Lei, Zhu, Xiao-Peng, Chen, Ling, Yang, Hui, Zhang, Ke-Bin, Lv, Sheng-Qing
Natura: Artigo
Lingua:Inglês
Pubblicazione: D.A. Spandidos 2017
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652242/
https://ncbi.nlm.nih.gov/pubmed/29098021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2017.6849
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