Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51

BACKGROUND: Endoplasmic reticulum (ER) stress results from protein misfolding imbalance and has been postulated as a therapeutic strategy. ER stress activates the unfolded protein response which leads to a complex cellular response, including the upregulation of aberrant protein degradation in the E...

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Bibliografiska uppgifter
I publikationen:Neuro Oncol
Huvudupphovsmän: Xipell, Enric, Aragón, Tomás, Martínez-Velez, Naiara, Vera, Beatriz, Idoate, Miguel Angel, Martínez-Irujo, Juan José, Garzón, Antonia García, Gonzalez-Huarriz, Marisol, Acanda, Arlet M., Jones, Chris, Lang, Frederick F., Fueyo, Juan, Gomez-Manzano, Candelaria, Alonso, Marta M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2016
Ämnen:
Basic and Translational Investigations
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933483/
https://ncbi.nlm.nih.gov/pubmed/26951384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now022
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