Pyrrolidine dithiocarbamate sensitizes U251 brain glioma cells to temozolomide via downregulation of MGMT and BCL-XL

The current study investigated the effect of pyrrolidine dithiocarbamate (PDTC) on the proliferation, apoptosis, cell cycle and sensitivity to temozolomide (TMZ) of the U251 glioma cell line. Proliferation, apoptosis and cell cycle analysis of U251 cells following treatment with PDTC and TMZ was det...

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Publicado en:Oncol Lett
Autores principales: Tang, Jun-Hai, Huang, Guo-Hao, Mou, Ke-Jie, Zhang, Eric Erquan, Li, Ningning, Du, Lei, Zhu, Xiao-Peng, Chen, Ling, Yang, Hui, Zhang, Ke-Bin, Lv, Sheng-Qing
Formato: Artigo
Lenguaje:Inglês
Publicado: D.A. Spandidos 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652242/
https://ncbi.nlm.nih.gov/pubmed/29098021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2017.6849
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