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Productive Coupling of Accessible Vβ14 Segments and DJβ Complexes Determines the Frequency of Vβ14 Rearrangement()

To elucidate mechanisms that regulate Vβ rearrangement, we generated and analyzed mice with a V(D)J recombination reporter cassette of germline Dβ-Jβ segments inserted into the endogenous Vβ14 locus (Vβ14(Rep)). As a control, we first generated and analyzed mice with the same Dβ-Jβ cassette targeted...

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Publicat a:J Immunol
Autors principals: Ranganath, Sheila, Carpenter, Andrea C., Gleason, Megan, Shaw, Albert C., Bassing, Craig H., Alt, Frederick W.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652044/
https://ncbi.nlm.nih.gov/pubmed/18250443
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