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Vβ Cluster Sequences Reduce the Frequency of Primary Vβ2 and Vβ14 Rearrangements
T cell receptor (TCR) β variable region exons are assembled from numerous gene segments in a highly ordered and regulated manner. To elucidate mechanisms and identify cis-acting elements that control Vβ rearrangement, we generated an endogenous TCRβ allele with only the Vβ2, Vβ4, and Vβ14 segments....
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2736105/ https://ncbi.nlm.nih.gov/pubmed/18792409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200838347 |
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