Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis

A multigenic locus at 3p13-14, spanning FOXP1 to SHQ1, is commonly deleted in prostate cancer and lost broadly in a range of cancers but has unknown significance to oncogenesis or prognosis. Here, we report that FOXP1-SHQ1 deletion cooperates with PTEN loss to accelerate prostate oncogenesis and tha...

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Udgivet i:Nat Commun
Main Authors: Hieronymus, Haley, Iaquinta, Phillip J., Wongvipat, John, Gopalan, Anuradha, Murali, Rajmohan, Mao, Ninghui, Carver, Brett S., Sawyers, Charles L.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651901/
https://ncbi.nlm.nih.gov/pubmed/29057879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01198-9
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