Improved Prefusion Stability, Optimized Codon Usage, and Augmented Virion Packaging Enhance the Immunogenicity of Respiratory Syncytial Virus Fusion Protein in a Vectored-Vaccine Candidate

Respiratory syncytial virus (RSV) is the most important viral agent of severe pediatric respiratory tract disease worldwide, but it lacks a licensed vaccine or suitable antiviral drug. A live attenuated chimeric bovine/human parainfluenza virus type 3 (rB/HPIV3) was developed previously as a vector...

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Bibliografske podrobnosti
izdano v:J Virol
Main Authors: Liang, Bo, Ngwuta, Joan O., Surman, Sonja, Kabatova, Barbora, Liu, Xiang, Lingemann, Matthias, Liu, Xueqiao, Yang, Lijuan, Herbert, Richard, Swerczek, Joanna, Chen, Man, Moin, Syed M., Kumar, Azad, McLellan, Jason S., Kwong, Peter D., Graham, Barney S., Collins, Peter L., Munir, Shirin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2017
Teme:
Vaccines and Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651718/
https://ncbi.nlm.nih.gov/pubmed/28539444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00189-17
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