Improved Prefusion Stability, Optimized Codon Usage, and Augmented Virion Packaging Enhance the Immunogenicity of Respiratory Syncytial Virus Fusion Protein in a Vectored-Vaccine Candidate

Respiratory syncytial virus (RSV) is the most important viral agent of severe pediatric respiratory tract disease worldwide, but it lacks a licensed vaccine or suitable antiviral drug. A live attenuated chimeric bovine/human parainfluenza virus type 3 (rB/HPIV3) was developed previously as a vector...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Liang, Bo, Ngwuta, Joan O., Surman, Sonja, Kabatova, Barbora, Liu, Xiang, Lingemann, Matthias, Liu, Xueqiao, Yang, Lijuan, Herbert, Richard, Swerczek, Joanna, Chen, Man, Moin, Syed M., Kumar, Azad, McLellan, Jason S., Kwong, Peter D., Graham, Barney S., Collins, Peter L., Munir, Shirin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651718/
https://ncbi.nlm.nih.gov/pubmed/28539444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00189-17
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