Packaging and Prefusion Stabilization Separately and Additively Increase the Quantity and Quality of Respiratory Syncytial Virus (RSV)-Neutralizing Antibodies Induced by an RSV Fusion Protein Expressed by a Parainfluenza Virus Vector

Human respiratory syncytial virus (RSV) and human parainfluenza virus type 3 (HPIV3) are major pediatric respiratory pathogens that lack vaccines. A chimeric bovine/human PIV3 (rB/HPIV3) virus expressing the unmodified, wild-type (wt) RSV fusion (F) protein from an added gene was previously evaluate...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Liang, Bo, Ngwuta, Joan O., Herbert, Richard, Swerczek, Joanna, Dorward, David W., Amaro-Carambot, Emerito, Mackow, Natalie, Kabatova, Barbora, Lingemann, Matthias, Surman, Sonja, Yang, Lijuan, Chen, Man, Moin, Syed M., Kumar, Azad, McLellan, Jason S., Kwong, Peter D., Graham, Barney S., Schaap-Nutt, Anne, Collins, Peter L., Munir, Shirin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068507/
https://ncbi.nlm.nih.gov/pubmed/27581977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01196-16
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