Profiling the dynamics of CSF and plasma Aβ reduction after treatment with JNJ-54861911, a potent oral BACE inhibitor

OBJECTIVES: Safety, tolerability, pharmacokinetics, and pharmacodynamics of a novel β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, JNJ-54861911, were assessed after single and multiple dosing in healthy participants. METHODS: Two randomized, placebo-controlled, double-blind st...

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Udgivet i:Alzheimers Dement (N Y)
Main Authors: Timmers, Maarten, Van Broeck, Bianca, Ramael, Steven, Slemmon, John, De Waepenaert, Katja, Russu, Alberto, Bogert, Jennifer, Stieltjes, Hans, Shaw, Leslie M., Engelborghs, Sebastiaan, Moechars, Dieder, Mercken, Marc, Liu, Enchi, Sinha, Vikash, Kemp, John, Van Nueten, Luc, Tritsmans, Luc, Streffer, Johannes Rolf
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2016
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651349/
https://ncbi.nlm.nih.gov/pubmed/29067308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trci.2016.08.001
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