Levodopa/Benserazide Loaded Microspheres Alleviate L-dopa Induced Dyskinesia through Preventing the Over-Expression of D1R/Shp-2/ERK1/2 Signaling Pathway in a Rat Model of Parkinson's Disease

Background: The long-term intermittent Levodopa (L-dopa) stimulation contributes to an aberrant activation of D1 receptor (D1R) mediated extracellular signal-regulated kinases1/2 (ERK1/2) in the striatal medium spiny neurons, resulting in the occurrence of L-dopa induced dyskinesia (LID). Recently,...

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Vydáno v:Front Aging Neurosci
Hlavní autoři: Wan, Ying, Wu, Na, Song, Lu, Wang, Xijin, Liu, Zhenguo, Yuan, Weien, Gan, Jing
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651254/
https://ncbi.nlm.nih.gov/pubmed/29093677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2017.00331
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