Levodopa/benserazide microsphere (LBM) prevents L-dopa induced dyskinesia by inactivation of the DR1/PKA/P-tau pathway in 6-OHDA-lesioned Parkinson's rats

L-3, 4-dihydroxyphenylalanine (L-dopa) is the gold standard for symptomatic treatment of Parkinson's disease (PD), but long-term therapy is associated with the emergence of L-dopa-induced dyskinesia (LID). In the present study, L-dopa and benserazide were loaded by poly (lactic-co-glycolic acid...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Xie, Cheng-long, Wang, Wen-Wen, Zhang, Su-fang, Yuan, Ming-Lu, Che, Jun-Yi, Gan, Jing, Song, Lu, Yuan, Wei-En, Liu, Zhen-Guo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267205/
https://ncbi.nlm.nih.gov/pubmed/25511986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07506
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