Levodopa/Benserazide PLGA Microsphere Prevents L-Dopa–Induced Dyskinesia via Lower β-Arrestin2 in 6-Hydroxydopamine Parkinson’s Rats

Prolonged pulsatile administration of Levodopa (L-dopa) can generate L-dopa–induced dyskinesia (LID). Numerous research has reported that continuous dopamine delivery (CDD) was useful in reducing the severity of LID. 6-OHDA lesioned rats were divided into two groups to receive intermittent L-dopa st...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Wang, Wen-Wen, Zhang, Xing-Ru, Lin, Jing-Ya, Zhang, Zeng-Rui, Wang, Zhen, Chen, Si-Yan, Xie, Cheng-Long
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593297/
https://ncbi.nlm.nih.gov/pubmed/31275144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00660
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