The Leukemic Stem Cell Niche: Adaptation to “Hypoxia” versus Oncogene Addiction

Previous studies based on low oxygen concentrations in the incubation atmosphere revealed that metabolic factors govern the maintenance of normal hematopoietic or leukemic stem cells (HSC and LSC). The physiological oxygen concentration in tissues ranges between 0.1 and 5.0%. Stem cell niches (SCN)...

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Detalhes bibliográficos
Publicado no:Stem Cells Int
Main Authors: Cheloni, Giulia, Poteti, Martina, Bono, Silvia, Masala, Erico, Mazure, Nathalie M., Rovida, Elisabetta, Lulli, Matteo, Dello Sbarba, Persio
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651121/
https://ncbi.nlm.nih.gov/pubmed/29118813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/4979474
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