Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles

The short QT syndrome (SQTS) is a rare cardiac disorder associated with arrhythmias and sudden death. Gain-of-function mutations to potassium channels mediating the rapid delayed rectifier current, I(Kr), underlie SQTS variant 1 (SQT1), in which treatment with Na(+) and K(+) channel blocking class I...

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Udgivet i:Front Physiol
Main Authors: Whittaker, Dominic G., Ni, Haibo, Benson, Alan P., Hancox, Jules C., Zhang, Henggui
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Physiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5649182/
https://ncbi.nlm.nih.gov/pubmed/29085299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00759
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