Induction of RNAi Responses by Short Left-Handed Hairpin RNAi Triggers

Small double-stranded, left-handed hairpin (LHP) RNAs containing a 5′-guide-loop-passenger-3′ structure induce RNAi responses by a poorly understood mechanism. To explore LHPs, we synthesized fully 2′-modified LHP RNAs targeting multiple genes and found all to induce robust RNAi responses. Deletion...

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Vydáno v:Nucleic Acid Ther
Hlavní autoři: Hagopian, Jonathan C., Hamil, Alexander S., van den Berg, Arjen, Meade, Bryan R., Eguchi, Akiko, Palm-Apergi, Caroline, Dowdy, Steven F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2017
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5649124/
https://ncbi.nlm.nih.gov/pubmed/28933656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2017.0686
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