Induction of RNAi Responses by Short Left-Handed Hairpin RNAi Triggers

Small double-stranded, left-handed hairpin (LHP) RNAs containing a 5′-guide-loop-passenger-3′ structure induce RNAi responses by a poorly understood mechanism. To explore LHPs, we synthesized fully 2′-modified LHP RNAs targeting multiple genes and found all to induce robust RNAi responses. Deletion...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nucleic Acid Ther
Main Authors: Hagopian, Jonathan C., Hamil, Alexander S., van den Berg, Arjen, Meade, Bryan R., Eguchi, Akiko, Palm-Apergi, Caroline, Dowdy, Steven F.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5649124/
https://ncbi.nlm.nih.gov/pubmed/28933656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2017.0686
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados