Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice

Sarcolipin (SLN) is an inhibitor of the sarco/endoplasmic reticulum (SR) Ca(2+) ATPase (SERCA) and is abnormally elevated in the muscle of Duchenne muscular dystrophy (DMD) patients and animal models. Here we show that reducing SLN levels ameliorates dystrophic pathology in the severe dystrophin/utr...

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Publicado no:Nat Commun
Main Authors: Voit, Antanina, Patel, Vishwendra, Pachon, Ronald, Shah, Vikas, Bakhutma, Mohammad, Kohlbrenner, Erik, McArdle, Joseph J., Dell’Italia, Louis J., Mendell, Jerry R., Xie, Lai-Hua, Hajjar, Roger J., Duan, Dongsheng, Fraidenraich, Diego, Babu, Gopal J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648780/
https://ncbi.nlm.nih.gov/pubmed/29051551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01146-7
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