Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice

Sarcolipin (SLN) is an inhibitor of the sarco/endoplasmic reticulum (SR) Ca(2+) ATPase (SERCA) and is abnormally elevated in the muscle of Duchenne muscular dystrophy (DMD) patients and animal models. Here we show that reducing SLN levels ameliorates dystrophic pathology in the severe dystrophin/utr...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Voit, Antanina, Patel, Vishwendra, Pachon, Ronald, Shah, Vikas, Bakhutma, Mohammad, Kohlbrenner, Erik, McArdle, Joseph J., Dell’Italia, Louis J., Mendell, Jerry R., Xie, Lai-Hua, Hajjar, Roger J., Duan, Dongsheng, Fraidenraich, Diego, Babu, Gopal J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648780/
https://ncbi.nlm.nih.gov/pubmed/29051551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01146-7
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