Sarcolipin overexpression impairs myogenic differentiation in Duchenne muscular dystrophy

Reduction in the expression of sarcolipin (SLN), an inhibitor of sarco(endo)plasmic reticulum (SR) Ca(2+)-ATPase (SERCA), ameliorates severe muscular dystrophy in mice. However, the mechanism by which SLN inhibition improves muscle structure remains unclear. Here, we describe the previously unknown...

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Udgivet i:Am J Physiol Cell Physiol
Main Authors: Niranjan, Nandita, Mareedu, Satvik, Tian, Yimin, Kodippili, Kasun, Fefelova, Nadezhda, Voit, Antanina, Xie, Lai-Hua, Duan, Dongsheng, Babu, Gopal J.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6850989/
https://ncbi.nlm.nih.gov/pubmed/31365291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00146.2019
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