Cardiac Specific Expression of Threonine 5 to Alanine Mutant Sarcolipin Results in Structural Remodeling and Diastolic Dysfunction

The functional importance of threonine 5 (T5) in modulating the activity of sarcolipin (SLN), a key regulator of sarco/endoplasmic reticulum (SR) Ca(2+) ATPase (SERCA) pump was studied using a transgenic mouse model with cardiac specific expression of threonine 5 to alanine mutant SLN (SLNT5A). In t...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Shanmugam, Mayilvahanan, Li, Dan, Gao, Shumin, Fefelova, Nadezhda, Shah, Vikas, Voit, Antanina, Pachon, Ronald, Yehia, Ghassan, Xie, Lai-Hua, Babu, Gopal J.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324845/
https://ncbi.nlm.nih.gov/pubmed/25671318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115822
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