OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs

Ectopic expression of lineage master regulators induces transdifferentiation. Whether cell fate transitions can be induced during various developmental stages has not been systemically examined. Here we discover that amongst different developmental stages, mouse embryonic stem cells (mESCs) are resi...

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Udgivet i:Nat Commun
Main Authors: Sheinboim, Danna, Maza, Itay, Dror, Iris, Parikh, Shivang, Krupalnik, Vladislav, Bell, Rachel E., Zviran, Asaf, Suita, Yusuke, Hakim, Ofir, Mandel-Gutfreund, Yael, Khaled, Mehdi, Hanna, Jacob H., Levy, Carmit
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647326/
https://ncbi.nlm.nih.gov/pubmed/29044103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01122-1
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