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Rapid chromatin switch in the direct reprogramming of fibroblasts to neurons
How transcription factors (TFs) reprogram one cell lineage to another remains unclear. Here, we define chromatin accessibility changes induced by the proneural TF Ascl1 throughout conversion of fibroblasts into induced neuronal (iN) cells. Thousands of genomic loci are affected as early as 12 hours...
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| Publicado no: | Cell Rep |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5646379/ https://ncbi.nlm.nih.gov/pubmed/28954238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.011 |
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