Rapid chromatin switch in the direct reprogramming of fibroblasts to neurons

How transcription factors (TFs) reprogram one cell lineage to another remains unclear. Here, we define chromatin accessibility changes induced by the proneural TF Ascl1 throughout conversion of fibroblasts into induced neuronal (iN) cells. Thousands of genomic loci are affected as early as 12 hours...

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Pubblicato in:Cell Rep
Autori principali: Wapinski, Orly L., Lee, Qian Yi, Chen, Albert C., Li, Rui, Corces, M. Ryan, Ang, Cheen Euong, Treutlein, Barbara, Xiang, Chaomei, Baubet, Valérie, Suchy, Fabian Patrik, Sankar, Venkat, Sim, Sopheak, Quake, Stephen R., Dahmane, Nadia, Wernig, Marius, Chang, Howard Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5646379/
https://ncbi.nlm.nih.gov/pubmed/28954238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.011
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