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Loss of tumor suppressor STAG2 promotes telomere recombination and extends the replicative lifespan of normal human cells
Sister chromatids are held together by cohesin, a tripartite ring with a peripheral SA1/2 subunit, where SA1 is required for telomere cohesion and SA2 for centromere cohesion. The STAG2 gene encoding SA2 is often inactivated in human cancer, but not in in a manner associated with aneuploidy. Thus, h...
Shranjeno v:
| izdano v: | Cancer Res |
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| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5645240/ https://ncbi.nlm.nih.gov/pubmed/28819029 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1260 |
| Oznake: |
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