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Evaluation of self-emulsified DIM-14 in dogs for oral bioavailability and in Nu/nu mice bearing stem cell lung tumor models for anticancer activity

3, 3-Diindolylmethane-14 (DIM-14), a novel lipophilic derivative of DIM, has demonstrated anticancer activity in different types of cancers. However, poor solubility and low oral bioavailability of DIM-14 limit its translational benefits in vivo. This study was carried out to improve the oral bioava...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Patel, Apurva R., Doddapaneni, Ravi, Andey, Terrick, Wilson, Heather, Safe, Stephen, Singh, Mandip
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645071/
https://ncbi.nlm.nih.gov/pubmed/26079185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2015.06.014
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