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Approaches to Improve the Oral Bioavailability and Effects of Novel Anticancer Drugs Berberine and Betulinic Acid

BACKGROUND: The poor bioavailability of Berberine (BBR) and Betulinic acid (BA) limits the development of these promising anticancer agents for clinical use. In the current study, BBR and BA in spray dried (SD) mucoadhesive microparticle formulations were prepared. METHODS: A patented dual channel s...

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Bibliografiske detaljer
Main Authors: Godugu, Chandraiah, Patel, Apurva R., Doddapaneni, Ravi, Somagoni, Jaganmohan, Singh, Mandip
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948684/
https://ncbi.nlm.nih.gov/pubmed/24614362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089919
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