The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis

ADAR proteins alter gene expression both by catalyzing adenosine (A) to inosine (I) RNA editing and binding to regulatory elements in target RNAs. Loss of ADARs affects neuronal function in all animals studied to date. Caenorhabditis elegans lacking ADARs exhibit reduced chemotaxis, but the targets...

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Publicado en:eLife
Autores principales: Deffit, Sarah N, Yee, Brian A, Manning, Aidan C, Rajendren, Suba, Vadlamani, Pranathi, Wheeler, Emily C, Domissy, Alain, Washburn, Michael C, Yeo, Gene W, Hundley, Heather A
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5644944/
https://ncbi.nlm.nih.gov/pubmed/28925356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28625
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