Targeting ATR/CHK1 pathway in acute myeloid leukemia to overcome chemoresistance

Resistance of acute myeloid leukemia to current therapies leads to frequent relapses. Identification of molecular mechanisms involved in chemoresistance constitutes a key challenge to define new therapeutic concepts. Here, we show that the ATR/CHK1 pathway, essential in maintaining genomic stability...

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Bibliographic Details
Published in:Mol Cell Oncol
Main Authors: David, Laure, Manenti, Stéphane, Récher, Christian, Hoffmann, Jean-Sébastien, Didier, Christine
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5644474/
https://ncbi.nlm.nih.gov/pubmed/29057300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2017.1289293
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