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Discovery of potent inhibitors of human β-tryptase from pre-equilibrated dynamic combinatorial libraries
Pre-equilibrated dynamic combinatorial libraries based on acyl hydrazone interchange of peptide-derived hydrazides and di- and tri-aldehydes have been used to discover potent inhibitors with nanomolar affinities for β-tryptase. To identify potent inhibitors the activity of the full library containin...
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| Publicat a: | Chem Sci |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Royal Society of Chemistry
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5644118/ https://ncbi.nlm.nih.gov/pubmed/29163876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4sc02943g |
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