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Discovery of DNA repair inhibitors by combinatorial library profiling

Small molecule inhibitors of DNA repair are emerging as potent and selective anti-cancer therapies, but the sheer magnitude of the protein networks involved in DNA repair processes poses obstacles to discovery of effective candidate drugs. To address this challenge, we used a subtractive combinatori...

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Detalhes bibliográficos
Main Authors: Moeller, Benjamin J., Sidman, Richard L., Pasqualini, Renata, Arap, Wadih
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057608/
https://ncbi.nlm.nih.gov/pubmed/21343400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2361
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