Mutation Spectrum Induced by 8-Bromoguanine, a Base Damaged by Reactive Brominating Species, in Human Cells

To date, the types of mutations caused by 8-bromoguanine (8BrG), a major base lesion induced by reactive brominating species during inflammation, in human cells and the 8BrG repair system remain largely unknown. In this study, we performed a supF forward mutation assay using a shuttle vector plasmid...

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Publicat a:Oxid Med Cell Longev
Autors principals: Shinmura, Kazuya, Kato, Hisami, Goto, Masanori, Tao, Hong, Inoue, Yusuke, Nakamura, Satoki, Yoshida, Haruki, Tsuzaki, Emi, Sugimura, Haruhiko
Format: Artigo
Idioma:Inglês
Publicat: Hindawi 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643121/
https://ncbi.nlm.nih.gov/pubmed/29098062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/7308501
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