RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease

Dysfunction of microglia is known to play an important role in Alzheimer’s disease (AD). Here, we investigated the role of RIPK1 in microglia mediating the pathogenesis of AD. RIPK1 is highly expressed by microglial cells in human AD brains. Using the amyloid precursor protein (APP)/presenilin 1 (PS...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Ofengeim, Dimitry, Mazzitelli, Sonia, Ito, Yasushi, DeWitt, Judy Park, Mifflin, Lauren, Zou, Chengyu, Das, Sudeshna, Adiconis, Xian, Chen, Hongbo, Zhu, Hong, Kelliher, Michelle A., Levin, Joshua Z., Yuan, Junying
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642727/
https://ncbi.nlm.nih.gov/pubmed/28904096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714175114
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