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De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures

The folding of natural proteins typically relies on hydrophobic packing, metal binding, or disulfide bond formation in the protein core. Alternatively, a 3D structure can be defined by incorporating a multivalent cross-linking agent, and this approach has been successfully developed for the selectio...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Dang, Bobo, Wu, Haifan, Mulligan, Vikram Khipple, Mravic, Marco, Wu, Yibing, Lemmin, Thomas, Ford, Alexander, Silva, Daniel-Adriano, Baker, David, DeGrado, William F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642715/
https://ncbi.nlm.nih.gov/pubmed/28973862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710695114
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