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De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures
The folding of natural proteins typically relies on hydrophobic packing, metal binding, or disulfide bond formation in the protein core. Alternatively, a 3D structure can be defined by incorporating a multivalent cross-linking agent, and this approach has been successfully developed for the selectio...
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Publicado no: | Proc Natl Acad Sci U S A |
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Main Authors: | , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5642715/ https://ncbi.nlm.nih.gov/pubmed/28973862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710695114 |
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