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De novo design of constrained and sequence-independent peptide scaffolds with topologically-formidable disulfide connectivities

Disulfide-rich peptides are interesting scaffolds for drug design and discovery. However, peptide scaffolds constrained by disulfide bonds, either naturally occurring or computationally designed, have been suffering from the elusive (oxidative) folding behavior complying with Anfinsen's dogma,...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Chem Sci
Main Authors: Zheng, Yiwu, Meng, Xiaoting, Wu, Yaqi, Zhao, Yibing, Wu, Chuanliu
פורמט: Artigo
שפה:Inglês
יצא לאור: Royal Society of Chemistry 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5869988/
https://ncbi.nlm.nih.gov/pubmed/29629120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc03956e
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