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Miscoding-induced stalling of substrate translocation on the bacterial ribosome

Directional transit of the ribosome along the messenger RNA (mRNA) template is a key determinant of the rate and processivity of protein synthesis. Imaging of the multistep translocation mechanism using single-molecule FRET has led to the hypothesis that substrate movements relative to the ribosome...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Alejo, Jose L., Blanchard, Scott C.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642701/
https://ncbi.nlm.nih.gov/pubmed/28973849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707539114
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