Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome

Negamycin is a natural product with broad-spectrum antibacterial activity and efficacy in animal models of infection. Although its precise mechanism of action has yet to be delineated, negamycin inhibits cellular protein synthesis and causes cell death. Here, we show that single point mutations with...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Olivier, Nelson B., Altman, Roger B., Noeske, Jonas, Basarab, Gregory S., Code, Erin, Ferguson, Andrew D., Gao, Ning, Huang, Jian, Juette, Manuel F., Livchak, Stephania, Miller, Matthew D., Prince, D. Bryan, Cate, Jamie H. D., Buurman, Ed T., Blanchard, Scott C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246262/
https://ncbi.nlm.nih.gov/pubmed/25368144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414401111
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