Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome

Negamycin is a natural product with broad-spectrum antibacterial activity and efficacy in animal models of infection. Although its precise mechanism of action has yet to be delineated, negamycin inhibits cellular protein synthesis and causes cell death. Here, we show that single point mutations with...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Proc Natl Acad Sci U S A
Main Authors: Olivier, Nelson B., Altman, Roger B., Noeske, Jonas, Basarab, Gregory S., Code, Erin, Ferguson, Andrew D., Gao, Ning, Huang, Jian, Juette, Manuel F., Livchak, Stephania, Miller, Matthew D., Prince, D. Bryan, Cate, Jamie H. D., Buurman, Ed T., Blanchard, Scott C.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2014
נושאים:
Physical Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246262/
https://ncbi.nlm.nih.gov/pubmed/25368144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414401111
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