The activation of SRC family kinases and focal adhesion kinase with the loss of the amplified, mutated EGFR gene contributes to the resistance to afatinib, erlotinib and osimertinib in human lung cancer cells

Second- and third-generation inhibitors of epidermal growth factor receptor (EGFR) tyrosine kinase activity (EGFR-TKIs) are improving the treatment of patients with non-small cell lung cancer. Here we established two sublines (BR1-8 and BR2-3) resistant to a second-generation inhibitor, afatinib, fr...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Murakami, Yuichi, Sonoda, Kahori, Abe, Hideyuki, Watari, Kosuke, Kusakabe, Daiki, Azuma, Koichi, Kawahara, Akihiko, Akiba, Jun, Oneyama, Chitose, Pachter, Jonathan A., Sakai, Kazuko, Nishio, Kazuto, Kuwano, Michihiko, Ono, Mayumi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2017
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642590/
https://ncbi.nlm.nih.gov/pubmed/29050315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19982
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