Acrolein induces mtDNA damages, mitochondrial fission and mitophagy in human lung cells

Acrolein (Acr), a highly reactive unsaturated aldehyde, can cause various lung diseases including asthma, chronic obstructive pulmonary disease (COPD), and lung cancer. We have found that Acr can damage not only genomic DNA but also DNA repair proteins causing repair dysfunction and enhancing cells’...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wang, Hsiang-Tsui, Lin, Jing-Heng, Yang, Chun-Hsiang, Haung, Chun-Hao, Weng, Ching-Wen, Maan-Yuh Lin, Anya, Lo, Yu-Li, Chen, Wei-Shen, Tang, Moon-Shong
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642564/
https://ncbi.nlm.nih.gov/pubmed/29050289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19710
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