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Acrolein preferentially damages nucleolus eliciting ribosomal stress and apoptosis in human cancer cells
Acrolein (Acr) is a potent cytotoxic and DNA damaging agent which is ubiquitous in the environment and abundant in tobacco smoke. Acr is also an active cytotoxic metabolite of the anti-cancer drugs cyclophosphamide and ifosfamide. The mechanisms via which Acr exerts its anti-cancer activity and cyto...
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| Veröffentlicht in: | Oncotarget |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Impact Journals LLC
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5348333/ https://ncbi.nlm.nih.gov/pubmed/27741518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12608 |
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