Effect of CpG methylation at different sequence context on acrolein- and BPDE-DNA binding and mutagenesis

Acrolein (Acr), an α,β-unsaturated aldehyde, is abundant in tobacco smoke and cooking and exhaust fumes. Acr induces mutagenic α- and γ- hydroxy-1,N(2)-cyclic propano-deoxyguanosine adducts in normal human bronchial epithelial cells. Our earlier work has found that Acr-induced DNA damage preferentia...

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Autors principals: Wang, Hsiang-Tsui, Weng, Mao-wen, Chen, Wen-chi, Yobin, Michael, Pan, Jishen, Chung, Fung-Lung, Wu, Xue-Ru, Rom, William, Tang, Moon-shong
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534198/
https://ncbi.nlm.nih.gov/pubmed/23042304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs323
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