Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases

[Image: see text] NOD2 (nucleotide-binding oligomerization domain-containing protein 2) is an internal pattern recognition receptor that recognizes bacterial peptidoglycan and stimulates host immune responses. Dysfunction of NOD2 pathway has been associated with a number of autoinflammatory disorder...

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Publicado en:ACS Med Chem Lett
Main Authors: He, Xiaohui, Da Ros, Sara, Nelson, John, Zhu, Xuefeng, Jiang, Tao, Okram, Barun, Jiang, Songchun, Michellys, Pierre-Yves, Iskandar, Maya, Espinola, Sheryll, Jia, Yong, Bursulaya, Badry, Kreusch, Andreas, Gao, Mu-Yun, Spraggon, Glen, Baaten, Janine, Clemmer, Leah, Meeusen, Shelly, Huang, David, Hill, Robert, Nguyen-Tran, Vân, Fathman, John, Liu, Bo, Tuntland, Tove, Gordon, Perry, Hollenbeck, Thomas, Ng, Kenneth, Shi, Jian, Bordone, Laura, Liu, Hong
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2017
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641954/
https://ncbi.nlm.nih.gov/pubmed/29057049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00258
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