Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine

In heart failure, the β-adrenergic receptors (βARs) become desensitized and uncoupled from heterotrimeric G proteins. This process is initiated by G protein-coupled receptor kinases (GRKs), some of which are upregulated in the failing heart making them desirable therapeutic targets. The serotonin re...

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Détails bibliographiques
Publié dans:J Med Chem
Auteurs principaux: Waldschmidt, Helen V., Homan, Kristoff T., Cato, Marilyn C., Cruz-Rodríguez, Osvaldo, Cannavo, Alessandro, Wilson, Michael W., Song, Jianliang, Cheung, Joseph Y., Koch, Walter J., Tesmer, John J. G., Larsen, Scott D.
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641445/
https://ncbi.nlm.nih.gov/pubmed/28323425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00112
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