Structure-Based Design, Synthesis and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors

G protein-coupled receptors (GPCRs) are central to many physiological processes. Regulation of this superfamily of receptors is controlled by GPCR kinases (GRKs), some of which have been implicated in heart failure. GSK180736A, developed as a Rho-associated coiled-coil kinase 1 (ROCK1) inhibitor, wa...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Waldschmidt, Helen V., Homan, Kristoff T., Cruz-Rodríguez, Osvaldo, Cato, Marilyn C., Waninger-Saroni, Jessica, Larimore, Kelly L., Cannavo, Alessandro, Song, Jianliang, Cheung, Joseph Y., Koch, Walter J., Tesmer, John J. G., Larsen, Scott D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890168/
https://ncbi.nlm.nih.gov/pubmed/27050625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b02000
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