Structure-Based Design, Synthesis and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors

G protein-coupled receptors (GPCRs) are central to many physiological processes. Regulation of this superfamily of receptors is controlled by GPCR kinases (GRKs), some of which have been implicated in heart failure. GSK180736A, developed as a Rho-associated coiled-coil kinase 1 (ROCK1) inhibitor, wa...

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Pubblicato in:J Med Chem
Autori principali: Waldschmidt, Helen V., Homan, Kristoff T., Cruz-Rodríguez, Osvaldo, Cato, Marilyn C., Waninger-Saroni, Jessica, Larimore, Kelly L., Cannavo, Alessandro, Song, Jianliang, Cheung, Joseph Y., Koch, Walter J., Tesmer, John J. G., Larsen, Scott D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890168/
https://ncbi.nlm.nih.gov/pubmed/27050625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b02000
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