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Synthesis and N-Methyl-D-aspartate (NMDA) Receptor Activity of Ketamine Metabolites
Ketamine is rapidly metabolized in the human body to a variety of metabolites, including the hydroxynorketamines. At least two hydroxynorketamines have significant antidepressant action in rodent models, with limited action against the N-methyl-D-aspartate (NMDA) receptor. The synthesis of 12 hydrox...
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| Publicado no: | Org Lett |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5641405/ https://ncbi.nlm.nih.gov/pubmed/28829612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.7b02177 |
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