Sphingosine-1-Phosphate and the S1P(3) Receptor Initiate Neuronal Retraction via RhoA/ROCK Associated with CRMP2 Phosphorylation

The bioactive lipid sphingosine-1-phosphate (S1P) is an important regulator in the nervous system. Here, we explored the role of S1P and its receptors in vitro and in preclinical models of peripheral nerve regeneration. Adult sensory neurons and motor neuron-like cells were exposed to S1P in an in v...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Quarta, Serena, Camprubí-Robles, Maria, Schweigreiter, Rüdiger, Matusica, Dusan, Haberberger, Rainer V., Proia, Richard L., Bandtlow, Christine E., Ferrer-Montiel, Antonio, Kress, Michaela
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641356/
https://ncbi.nlm.nih.gov/pubmed/29066950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00317
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