Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells

Antibodies targeting the PD-1/PD-L1 immune checkpoint achieved spectacular success in anticancer therapy in the recent years. In contrast, no small molecules with cellular activity have been reported so far. Here we provide evidence that small molecules are capable of alleviating the PD-1/PD-L1 immu...

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保存先:
書誌詳細
出版年:Oncotarget
主要な著者: Skalniak, Lukasz, Zak, Krzysztof M., Guzik, Katarzyna, Magiera, Katarzyna, Musielak, Bogdan, Pachota, Magdalena, Szelazek, Bozena, Kocik, Justyna, Grudnik, Przemyslaw, Tomala, Marcin, Krzanik, Sylwia, Pyrc, Krzysztof, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A.
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2017
主題:
Research Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641120/
https://ncbi.nlm.nih.gov/pubmed/29069777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20050
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