Mutant IDH1 and Thrombosis in Gliomas

Mutant isocitrate dehydrogenase 1 (IDH1) is common in gliomas, and produces D-2-hydroxyglutarate (D-2-HG). The full effects of IDH1 mutations on glioma biology and tumor microenvironment are unknown. We analyzed a discovery cohort of 169 World Health Organization (WHO) grade II-IV gliomas, followed...

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Publicat a:Acta Neuropathol
Autors principals: Unruh, Dusten, Schwarze, Steven R., Khoury, Laith, Thomas, Cheddhi, Wu, Meijing, Chen, Li, Chen, Rui, Liu, Yinxing, Schwartz, Margaret A., Amidei, Christina, Kumthekar, Priya, Benjamin, Carolina G., Song, Kristine, Dawson, Caleb, Rispoli, Joanne M., Fatterpekar, Girish, Golfinos, John G., Kondziolka, Douglas, Karajannis, Matthias, Pacione, Donato, Zagzag, David, McIntyre, Thomas, Snuderl, Matija, Horbinski, Craig
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640980/
https://ncbi.nlm.nih.gov/pubmed/27664011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-016-1620-7
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