Mutant IDH1 and seizures in patients with glioma

OBJECTIVE: Because the d-2-hydroxyglutarate (D2HG) product of mutant isocitrate dehydrogenase 1 (IDH1(mut)) is released by tumor cells into the microenvironment and is structurally similar to the excitatory neurotransmitter glutamate, we sought to determine whether IDH1(mut) increases the risk of se...

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Publicat a:Neurology
Autors principals: Chen, Hao, Judkins, Jonathon, Thomas, Cheddhi, Wu, Meijing, Khoury, Laith, Benjamin, Carolina G., Pacione, Donato, Golfinos, John G., Kumthekar, Priya, Ghamsari, Farhad, Chen, Li, Lein, Pamela, Chetkovich, Dane M., Snuderl, Matija, Horbinski, Craig
Format: Artigo
Idioma:Inglês
Publicat: Lippincott Williams & Wilkins 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5419985/
https://ncbi.nlm.nih.gov/pubmed/28404805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000003911
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