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Molecular mechanism of synergy between the antimicrobial peptides PGLa and magainin 2

PGLa and magainin 2 (MAG2) are amphiphilic α-helical membranolytic peptides from frog skin with known synergistic antimicrobial activity. By systematically mutating residues in the two peptides it was possible to identify the ones crucial for the synergy, as monitored by biological assays, fluoresce...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zerweck, Jonathan, Strandberg, Erik, Kukharenko, Olga, Reichert, Johannes, Bürck, Jochen, Wadhwani, Parvesh, Ulrich, Anne S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640672/
https://ncbi.nlm.nih.gov/pubmed/29030606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12599-7
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