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Molecular mechanism of synergy between the antimicrobial peptides PGLa and magainin 2

PGLa and magainin 2 (MAG2) are amphiphilic α-helical membranolytic peptides from frog skin with known synergistic antimicrobial activity. By systematically mutating residues in the two peptides it was possible to identify the ones crucial for the synergy, as monitored by biological assays, fluoresce...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Zerweck, Jonathan, Strandberg, Erik, Kukharenko, Olga, Reichert, Johannes, Bürck, Jochen, Wadhwani, Parvesh, Ulrich, Anne S.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640672/
https://ncbi.nlm.nih.gov/pubmed/29030606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12599-7
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