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Hydrophobic mismatch demonstrated for membranolytic peptides, and their use as molecular rulers to measure bilayer thickness in native cells

Hydrophobic mismatch is a well-recognized principle in the interaction of transmembrane proteins with lipid bilayers. This concept was extended here to amphipathic membranolytic α-helices. Nine peptides with lengths between 14 and 28 amino acids were designed from repeated KIAGKIA motifs, and their...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Grau-Campistany, Ariadna, Strandberg, Erik, Wadhwani, Parvesh, Reichert, Johannes, Bürck, Jochen, Rabanal, Francesc, Ulrich, Anne S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224518/
https://ncbi.nlm.nih.gov/pubmed/25807192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09388
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